IMT1B

SKU: orb1298591

Description

IMT1B (LDC203974) is an orally bioavailable, specific allosteric inhibitor of mitochondrial RNA polymerase (POLRMT) that suppresses mtDNA transcription, conferring anti-tumor activity. It is used in cancer research to study mitochondrial metabolism and has demonstrated efficacy in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 2304621-06-3
• MW: 473.88
• Purity: 98.26% (May vary between batches)
• Formula: C₂₄H₂₁ClFNO₆
• SMILES: C[C@@H](Oc1ccc2c(cc(=O)oc2c1)-c1ccc(F)cc1Cl)C(=O)N1CCC[C@@H](C1)C(O)=O
• Target: DNA/RNA Synthesis
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (10.55 mM);DMSO:16.9 mg/mL (35.66 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RNASynthesis, RNA Synthesis, RNA, polymerase, oxidative, OXPHOS, POLRMT, phosphorylation, mitochondrial, inhibit, mtDNA, IMT1B, IMT-1B, Inhibitor, LDC 203974, LDC203974, LDC-203974, human, 3-Piperidinecarboxylic acid, 1-[(2R)-2-[[4-(2-chloro-4-fluorophenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-1-oxopropyl]-, (3S)-, anti-tumour, DNASynthesis, DNA Synthesis, DNA

Compound Identifiers

PubChem CID

138490769