iMQT_020

SKU: orb3174252

Description

iMQT_020 is a selective allosteric SLC1A5_var inhibitor. It disrupts the trimer assembly of SLC1A5_var, leading to a metabolic crisis in cancer cells and selectively inhibiting their growth. iMQT_020 reduces compensatory glutamine metabolism and oxidative phosphorylation, causing widespread metabolic disruption in cancer cells. It lowers GSH levels while increasing intracellular and mitochondrial ROS levels. Additionally, iMQT_020 induces apoptosis and ferroptosis and upregulates PD-L1 expression through epigenetic mechanisms. This compound is applicable in research on pancreatic, lung, and colon cancers.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research

Key Properties

• CAS Number: 2463893-46-9
• MW: 306.68
• Formula: C₁₄H₈ClFN₂O₃
• SMILES: O=C1NC(=O)C2=CC(=CC=C2N1)C=3C=C(Cl)C(O)=CC3F
• Target: PD-1/PD-L1,Glutathione Peroxidase,ROS,Ferroptosis,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PD-1/PD-L1,Glutathione Peroxidase,ROS,Ferroptosis,Apoptosis