Imiquimod 2HCl

SKU: orb2283882

Description

Imiquimod 2HCl is a synthetic TLR7 agonist that functions as an immune response modifier with demonstrated antiviral and antitumor properties. It is widely utilized in preclinical research for modeling psoriasis-like inflammation in mice and for investigating conditions such as periorbital skin cancer, pemphigus foliaceus, and COVID-19 pathogenesis.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2995277-02-4
• MW: 313.23
• Purity: 99.41% (May vary between batches)
• Formula: C₁₄H₁₈Cl₂N₄
• SMILES: NC1=NC2=C(C3=C1N=CN3CC(C)C)C=CC=C2.Cl.Cl
• Target: Antiviral,Autophagy,SARS-CoV,TLR,HSV

Bioactivity

• In Vitro:
  In 8-11 week-old BALB/c mice, Imiquimod 2HCl (3.125 mg/day for 6 days; applied to the skin) induces signs of erythema, scaling, and thickening on the mice's back skin, accompanied by hyperproliferative keratinocytes and disrupted epidermal differentiation.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Imiquimod 2HCl(99011-02-6 Free base), Imiquimod2HCl(99011026Freebase), antiviral;TLR7

Compound Identifiers

PubChem CID

170913014