Imidazole ketone erastin

SKU: orb1225890

Description

Imidazole ketone erastin (IKE, Ferroptosis inducer IKE) is a potent, metabolically stable inhibitor of system xc- and inducer of ferroptosis potentially suitable for in vivo applications; potently reduces DLBCL cell number with IC50 of <100 nM (SUDHL6 cell IC50=1 nM); exerts antitumor effect by inhibiting system xc-, leading to glutathione depletion (GSH depletion IC50=34 nM, SUDHL6 cells), lipid peroxidation, and the induction of ferroptosis biomarkers both in vitro and in vivo, induced lipid peroxidation in tumor tissue.

Key Properties

• CAS Number: 1801530-11-9
• MW: 655.152
• Purity: >98% (HPLC)
• Formula: C₃₅H₃₅ClN₆O₅
• SMILES: O=C1N(C2=CC(C(CN3C=NC=C3)=O)=CC=C2OC(C)C)C(CN4CCN(C(COC5=CC=C(Cl)C=C5)=O)CC4)=NC6=C1C=CC=C6
• Target: Ferroptosis
• Solubility: DMSO : ≥ 125 mg/mL 190.80 mM

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ferroptosis inducer IKE | IKE

Quick Database Links

Gene Symbol

Ferroptosis