Imeglimin hydrochloride

SKU: orb1220400

Description

Imeglimin hydrochloride prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration.(In Vitro):Preincubation with Imeglimin (10 mM for 4 h or 100 μM for 24 h) also fully prevented tert-butylhydroperoxide (tBH)-induced cell death.(In Vivo):Imeglimin (200 mg/kg b.i.d. by oral gavage during the last 6 weeks of HFHSD feeding) significantly decreases hyperglycemia, and restores normal glucose tolerance.

Key Properties

• CAS Number: 775351-61-6
• MW: 191.66
• Purity: >98% (HPLC)
• Formula: C₆H₁₄ClN₅
• SMILES: C[C@@H]1N=C(N)NC(N(C)C)=N1.Cl
• Target: mitochondrial phospholipid
• Solubility: DMSO:25 mg/mL (130.44 mM)

Bioactivity

• In Vivo:
  Imeglimin (200 mg/kg b. i. d. by oral gavage during the last 6 weeks of HFHSD feeding) significantly decreases hyperglycemia, and restores normal glucose tolerance. Animal model: Male C57BL/6JOlaHsd mice (4 weeks old). Dosage: 200 mg/kg. Administration: Oral gavage; b. i. d. ; 6 weeks. Result: A slight decrease in body weight and food intake associated with some diarrhea was observed but only during the first few days of treatment.
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• In Vitro:
  Preincubation with Imeglimin (10 mM for 4 h or 100 μM for 24 h) also fully prevented tert-butylhydroperoxide (tBH)-induced cell death. Cell Viability Assay Cell line: Human endothelial cells (HMEC-1). Concentration: 100 μM and10 mM. Incubation time: 100 μM for 24 h, 10 mM for 4 h. Result: Prevention of cell death.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

EMD 387008 hydrochloride

Quick Database Links

Gene Symbol

mitochondrial phospholipid