iMDK

SKU: orb1298082

Description

iMDK

Research Area

Signal Transduction

Key Properties

• CAS Number: 881970-80-5
• MW: 376.4
• Purity: 99.99% (May vary between batches)
• Formula: C₂₁H₁₃FN₂O₂S
• SMILES: Fc1ccc(Cc2cn3cc(nc3s2)-c2cc3ccccc3oc2=O)cc1
• Target: PI3K
• Solubility: DMSO:3.77 mg/mL (10.02 mM)

Bioactivity

• In Vivo:
  Intraperitoneally injection with 100 μl of iMDK ( (9 mg/kg/day) and ; oral administion of PD0325901 (5 mg/kg) effectively reduced lung tumor growth in a xenograft mouse model.
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• In Vitro:
  Administration of iMDK (50-500 nM) for 72 h quarterhydrate suppressed AKT phosphorylation in H441 lung adenocarcinoma cells after treatment dose-dependently. In contrast, iMDK quarterhydrate robustly increases p-ERK.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

midkine, NSCLC, inhibit, factor, growth, Inhibitor, iMDK, MDK, PI3K, Phosphoinositide 3-kinase

Compound Identifiers

PubChem CID

15991416