IMB-808

SKU: orb1702176

Description

IMB-808 is a dual LXRα/β agonist that induces ABCA1-mediated cholesterol efflux in HepG2 cells without promoting lipogenesis. This mechanism supports its application in atherosclerosis research, including in vitro studies on reverse cholesterol transport.

Research Area

Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 870768-70-0
• MW: 380.32
• Purity: 99.93%
• Formula: C₁₈H₁₅F₃N₂O₄
• SMILES: O=C(C1=CC=C2OCCOC2=C1)N(C)CC(=O)NC3=CC=C(F)C(F)=C3F
• Target: Liver X Receptor,Antibacterial
• Solubility: DMSO:200 mg/mL (525.87 mM)

Bioactivity

• Target IC50:
  LXRα:0.15 μM (EC50)|LXRβ:0.53 μM (EC50)
• In Vitro:
  IMB-808 exhibited a significant dose-dependent effect in the concentration range of 0.001 μM to 30 μM by activating LXRβ with an EC50 of 0.53 μM. In addition, IMB-808 was able to activate LXRα in a dose-dependent manner in a luciferase reporter gene assay with the GAL4-pGL4-luc reporter plasmid with an EC50 of 0.15 μM. M. IMB-808 (0 μM-10 μM; 18 hours) significantly increased the protein and mRNA levels of ABCG1 and ABCA1 in RAW264.7 macrophage. IMB-808 (0.1 μM-10 μM; 24 h) enhanced cholesterol efflux capacity in a dose-dependent manner while decreasing cellular cholesterol concentration in cell lines.

Storage & Handling

• Storage: store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

IMB 808, IMB808, IMB-808

Compound Identifiers

PubChem CID

8001903