Imanixil

SKU: orb1707188

Description

Imanixil (HOE-402 free base) is a hypolipidemic small molecule that lowers cholesterol by inducing LDL receptor expression and inhibiting VLDL production. Its antiatherogenic properties make it a useful research tool for studying lipid metabolism in both in vitro and in vivo models of hypercholesterolemia.

Research Area

Metabolism Research

Key Properties

• CAS Number: 75689-93-9
• MW: 394.35
• Purity: >99.99% (May vary between batches)
• Formula: C₁₇H₁₇F₃N₆O₂
• SMILES: CC1(C)CN(C(=O)N1)c1ncc(C(=O)Nc2cccc(c2)C(F)(F)F)c(N)n1
• Target: LDL,LDLR
• Solubility: DMSO:80 mg/mL (202.87 mM)

Bioactivity

• In Vivo:
  Treatment with 0.05% (w/w) Imanixil (HOE-402(free base)) resulted in a maximal reduction of serum cholesterol levels in wild-type LDLR+/0 and LDLR0/0 mice by 53%, 56%, and 73%, respectively (P<0.05), and a reduction of very low-density lipoprotein (VLDL), intermediate-density lipoprotein (IDL), and low-density lipoprotein (LDL) cholesterol levels, while high-density lipoprotein (HDL) cholesterol levels increased. (LDL) cholesterol levels, and elevated high-density lipoprotein (HDL) cholesterol levels, Imanixil (HOE-402 (free base)) inhibits the production of VLDL, thereby attenuating the development of atherosclerosis.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

VLDL, HOE-402 free base, HOE-402(free base), Imanixil

Compound Identifiers

PubChem CID

216289