IM-156 (acetate)

SKU: orb1693752

Description

IM-156 acetate is an orally bioavailable small molecule that activates AMPKα and NADH dehydrogenase while inhibiting mitochondrial oxidative phosphorylation. It has demonstrated efficacy in reducing chlorhexadiene-induced peritoneal fibrosis and suppressing tumor growth in preclinical rodent models.

Key Properties

• CAS Number: 2043654-54-0
• MW: 375.35
• Purity: 90.00%
• Formula: C₁₅H₂₀F₃N₅O₃
• SMILES: O=C(O)C.FC(F)(F)OC1=CC=C(C=C1)NC(=N)NC(=N)N2CCCC2
• Target: Others
• Solubility: DMF:1 mg/mL (2.66 mM);DMSO:1 mg/mL (2.66 mM);Ethanol:1 mg/mL (2.66 mM)

Bioactivity

• Target IC50:
  NADH dehydrogenase:2.2 µM|OCR:3.3 µM
• In Vivo:
  It reduces the oxygen consumption rate (OCR; IC50 = 3.3 µM) and decreases mitochondrial ATP production in Eµ-Myc mouse lymphoma cells.1 IM-156 (10, 30, and 50 µM) increases AMPKα activity in primary rat peritoneal mesothelial cells and protects against chlorhexidine-induced peritoneal fibrosis in rats when administered at a dose of 1 mg/kg.2 It reduces tumor growth in an AT-84 murine oral cancer model and decreases age-related decline in novel object recognition, spatial working, and contextual memory in mice.
• In Vitro:
  IM-156 is an inhibitor of mitochondrial complex I, also known as an activator of NADH dehydrogenase (IC50 = 2.2 µM) and AMP-activated protein kinase α (AMPKα).

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AMPK, HL 271 Acetate, HL271 Acetate, HL271 acetate, HL-271 Acetate, IM 156 Acetate, IM156 Acetate, IM-156 Acetate, OXPHOS, NADH dehydrogenase

Compound Identifiers

PubChem CID

162322721