Ilorasertib hydrochloride

SKU: orb1709423

Description

Ilorasertib hydrochloride is a potent, ATP-competitive inhibitor targeting Aurora kinases (A, B, C) and other kinases including RET and PDGFRβ. It is utilized in cancer research to study cell cycle progression and tumorigenesis in both cellular and animal models.

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Signal Transduction

Key Properties

• CAS Number: 1847485-91-9
• MW: 525
• Purity: 98.45% (May vary between batches)
• Formula: C₂₅H₂₂ClFN₆O₂S
• SMILES: Cl.Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12
• Target: VEGFR,PDGFR,Aurora Kinase
• Solubility: DMSO:41.67 mg/mL (79.37 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.81 mM)

Bioactivity

• Target IC50:
  CSF1R:3 nM|PDGFRβ:13 nM|Aurora B (Y156H):12 nM|PDGFRα:11 nM|Aurora B:7 nM|Aurora A:120 nM|c-Kit:20 nM|FLT3:1 nM|VEGFR2:2 nM|VEGFR3:43 nM|VEGFR1:1 nM|Aurora C:1 nM

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

FLT3, Ilorasertib hydrochloride, Ilorasertib Hydrochloride, c-KIT, CSF-1R, ABT 348 Hydrochloride, ABT348 Hydrochloride, ABT-348 Hydrochloride, ABT-348 hydrochloride, Aurora A, Aurora B, Aurora B (Y156H), Aurora C, Aurora Kinase, AuroraKinase, PDGFRβ, PDGFRα, VEGFR1, VEGFR2, VEGFR3

Compound Identifiers

PubChem CID

54759636