Ilexsaponin A1

SKU: orb1222881

Description

Ilexsaponin A shows protective effects on ischemia-reperfusion-induced myocardial injury through anti-apoptotic pathway.

Key Properties

• CAS Number: 108524-93-2
• MW: 664.83
• Purity: >98% (HPLC)
• Formula: C₃₆H₅₆O₁₁
• SMILES: [H][C@@]1([C@]2(CCC([C@]3(C(O)=O)C)[C@@]1(CC[C@@H]3O)C)C)CC=C4[C@@]5([C@](O)([C@@H](CC[C@]5(C(O[C@@H]([C@@H]6O)O[C@@H]([C@H]([C@@H]6O)O)CO)=O)CC[C@]42C)C)C)[H]
• Target: PLK
• Solubility: In Vitro: DMSO : 100 mg/mL (150.42 mM)

Bioactivity

• In Vivo:
  Ilexsaponin A (10 or 40 mg/kg) reduce the myocardial infarct size in a dose dependent manner in male Sprague-Dawley rats weighing 280-320 g.
• In Vitro:
  Ilexsaponin Asignificantly reduces proapoptotic proteins including caspase-3, cleaved caspase-3 and bax and increases anti-apoptotic protein bcl-2 in hypoxia/reoxygenation cardiomyocytes. Ilexsaponin A treatment increases the expression levels of p-Akt in hypoxia/reoxygenation cellular model and myocardial ischemia/reperfusion animal model.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PLK