Ilexgenin A

SKU: orb1304696

Description

Ilexgenin A is a novel pentacyclic triterpenoid isolated from Ilex hainanensis Merr. Research indicates it exhibits anti-inflammatory and antioxidant activities, making it a compound of interest for metabolic and cardiovascular disease studies in vitro and in vivo.

Research Area

Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 108524-94-3
• MW: 502.68
• Purity: 99.75% (May vary between batches)
• Formula: C₃₀H₄₆O₆
• SMILES: [H][C@@]12CC[C@]3(C)[C@]([H])(CC=C4[C@]5([H])[C@](C)(O)[C@H](C)CC[C@@]5(CC[C@@]34C)C(O)=O)[C@@]1(C)CC[C@H](O)[C@]2(C)C(O)=O
• Target: IL Receptor|||TNF
• Solubility: DMSO:11 mg/mL (21.88 mM);10% DMSO+90% Corn Oil:1 mg/mL (1.99 mM)

Bioactivity

• In Vitro:
  Ilexgenin A (IA), a novel pentacyclic triterpenoid, is a compound extracted from leaves of Ilex hainanensis Merr.treatment with IA attenuated atherosclerosis in high-fat diet-induced apolipoprotein E deficient mice via a series of effects involving regulation of lipid parameters, decrease of atherosclerosis-related indexes, inhibition of inflammatory cytokines secretion and pathological changes of main organs. The underlying mechanism of IA was investigated on oxidized low-density lipoprotein (Ox-LDL)-induced THP-1 cells. Pre-treatment with IA decreased active inflammation cytokines involving interleukin-6 (IL-6), IL-1 and tumor necrosis factor-α (TNF-α) expression in a concentration-dependent manner.IA inhibited the phosphatidylinositol 3-kinase (PI3K), protein kinase B (Akt), IKKα phosphorylation and NF-κB activity induced by Ox-LDL. Overall, these findings define IA as a novel drug candidate for anti-atherosclerotic therapy.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Akt, Caspase, cancer, AMPK, LDL, IkB, IL Receptor, hainanensis, ERK, Inhibitor, inhibit, inflammation, ILReceptor, Ilex, Ilexgenin A, NF-κB, NO, pentacyclic, PKC, PI3K, ROS, TNF-α, STAT, triterpenoid, VEGFR

Compound Identifiers

PubChem CID

21672638