IKZF2-degrader 2

SKU: orb3175242

Description

IKZF2-degrader 2 is a selective, orally active molecular glue degrader for IKZF2, with DC50 values of 0.5 nM (HiBit) and 1.8 nM (FACS). It facilitates ubiquitination and degradation of target proteins by recruiting the CRL4-CRBN E3 ubiquitin ligase. IKZF2-degrader 2 shows moderate degradation activity against SALL4 (DC50 of 9 nM) but does not significantly degrade IKZF1, IKZF3, CK1α, or GSPT1. This compound is suitable for research in cancer immunology.

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2983841-00-3
• MW: 509.97
• Formula: C₂₆H₂₅ClFN₅O₃
• SMILES: O=C1C=2C=CC(=C(F)C2CN1C3C(=O)NC(=O)CC3)C=4N=C5C(C=CN5C)=C(C4Cl)CN6CCCC6
• Target: Molecular Glues,IKZF

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Molecular Glues,IKZF