IKKβ-IN-7

SKU: orb3211500

Description

IKKβ-IN-7 is an IKKβ inhibitor with an IC50 value of 9.44 μM. It induces DNA damage, S-phase cell cycle arrest, ROS accumulation, loss of mitochondrial membrane potential, and apoptosis (apoptosis). IKKβ-IN-7 inhibits the phosphorylation of p65 and IκBα, blocks nuclear translocation of p65, and modulates NF-κB-regulated genes. It suppresses tumor growth in xenograft models, shows activity against colorectal cancer, and exhibits low cytotoxicity to normal cells. IKKβ-IN-7 is applicable in colorectal cancer research.

Key Properties

• CAS Number: 3117527-92-8
• MW: 786.82
• Formula: C₄₅H₄₂N₂O₁₁
• SMILES: C(C)C1=C2C(C=3N(C2)C(=O)C4=C(C3)[C@](CC)(O)C(=O)OC4)=NC=5C1=CC(OC(=O)C6=C(C(OC/C=7/CC[C@@]8([C@@]([C@@]9([C@@](C)(CC\C7)O9)[H])(OC(=O)C8=C)[H])[H])=O)C=CC=C6)=CC5
• Target: Apoptosis,IκB/IKK,ROS,Bcl-2 Family,NF-κB

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,IκB/IKK,ROS,Bcl-2 Family,NF-κB