IKKβ-IN-6

SKU: orb3211239

Description

IKKβ-IN-6 is an anti-tumor agent. This compound effectively inhibits IKKβ (IC50: 18.24 μM), thereby reducing the phosphorylation of p65 and IκBα, preventing p65 nuclear translocation, and subsequently regulating NF-κB-controlled genes. Additionally, IKKβ-IN-6 targets topoisomerase I (Topo I), inducing DNA damage, ROS accumulation, mitochondrial membrane potential loss, and S phase arrest. It is applicable in colorectal cancer research.

Key Properties

• CAS Number: 3117527-91-7
• MW: 758.77
• Formula: C₄₃H₃₈N₂O₁₁
• SMILES: O=C1N2C(C=3C(C2)=CC=4C(N3)=CC=C(OC(=O)C5=C(C(OC/C=6/CC[C@@]7([C@@]([C@@]8([C@@](C)(CC\C6)O8)[H])(OC(=O)C7=C)[H])[H])=O)C=CC=C5)C4)=CC9=C1COC(=O)[C@@]9(CC)O
• Target: Topoisomerase,ROS,Bcl-2 Family,NF-κB,Apoptosis,IκB/IKK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Topoisomerase,ROS,Bcl-2 Family,NF-κB,Apoptosis,IκB/IKK