Ikarugamycin

SKU: orb1707192

Description

Ikarugamycin is a Streptomyces-derived macrolide antibiotic with antiprotozoal activity. It functions as a clathrin-mediated endocytosis (CME) inhibitor and induces apoptosis through caspase activation, making it a useful tool for studying cell death pathways and intracellular trafficking in vitro.

Research Area

Cell Biology, Infectious Disease & Virology, Protein Biochemistry

Key Properties

• CAS Number: 36531-78-9
• MW: 478.62
• Formula: C₂₉H₃₈N₂O₄
• SMILES: C(C)[C@H]1[C@]2([C@@]([C@@]3([C@@]([C@@]4([C@@](C3)(/C=C/C(=O)C5=C(O)[C@@](NC5=O)(CCCNC(=O)/C=C\C4)[H])[H])[H])(C=C2)[H])[H])(C[C@H]1C)[H])[H]
• Target: Others,Antibiotic,Apoptosis,Caspase

Bioactivity

• In Vitro:
  In H1299 cells, the IC50 value of Ikarugamycin was 2.7 μM, and it significantly inhibited TfnR endocytosis at a concentration of 4 μM .

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Clathrin-mediated endocytosis, Ikarugamycin

Compound Identifiers

PubChem CID

97042223