IKarisoside A

SKU: orb1690044

Description

IKarisoside A

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 55395-07-8
• MW: 500.49
• Purity: 99.83%
• Formula: C₂₆H₂₈O₁₀
• SMILES: C[C@@H]1O[C@@H](Oc2c(oc3c(CC=C(C)C)c(O)cc(O)c3c2=O)-c2ccc(O)cc2)[C@H](O)[C@H](O)[C@H]1O
• Target: NO Synthase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4 mM);DMSO:50 mg/mL (99.9 mM);Ethanol:1 mg/mL (2 mM)

Bioactivity

• In Vitro:
  Ikarisoside A is a natural flavonol glycoside derived from plants o the genus Epimedium, which have been used in Traditional Chinese Medicine as tonics, antirheumatics, and aphrodisiacs. We found that Ikarisoside A (1-100 μM) concentration dependently inhibite the secretion of catecholamines induced by acetylcholine, a physiological secretagogue and agonist of nicotinic acetylcholine receptors. Ikarisoside A had little effect on catecholamine secretion induced by veratridine and 56 mM K(+). Ikarisoside A (1-100 μM) also inhibited (22)Na(+) influx and (45)Ca(2+) influx induced by acetylcholine in a concentration dependent manner similar to that of catecholamine secretion. In Xenopus oocytes expressing α3β4 nicotinic acetylcholine receptors, Ikarisoside A (0.1 100 μM) directly inhibite the current evoked by acetylcholine. It also suppressed (14)C-catecholamine synthesis and tyrosine hydroxylase activity induced by acetylcholine at 1-100 μM and 10-100 μM, respectively the present findings suggest that Ikarisoside A inhibits acetylcholine-induced catecholamine secretion and synthesis by suppression of nicotinic acetylcholine receptor-ion channels in bovine adrenal medullary cells

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Baohuoside II, NOSynthase, NO Synthase, IKarisoside A, Icarisoside-

Compound Identifiers

PubChem CID

5481982