IK-930

SKU: orb1819060

Description

IK-930 is a potent, orally bioavailable small molecule inhibitor of the TEAD transcription factors, exhibiting sub-micromolar activity (EC50 < 0.1 µM). It is a valuable research tool for investigating the Hippo signaling pathway in cancer research, with utility in both in vitro cellular assays and in vivo preclinical models.

Research Area

Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2563892-44-2
• MW: 424.44
• Purity: 99.89% (May vary between batches)
• Formula: C₁₉H₁₉F₃N₄O₂S
• SMILES: N(CC1=CC=C(C(F)(F)F)C=C1)C2=C(C=C(S(NC)(=O)=O)C=C2)C=3N=CN(C)C3
• Target: YAP
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.77 mM);DMSO:117.5 mg/mL (276.84 mM)

Bioactivity

• Target IC50:
  TEAD:<0.1 µM(EC50)
• In Vivo:
  IK-930 (compound I-32) (10 mg/kg; p.o.) demonstrates favorable pharmacokinetic parameters in BALB/c mice, with a Cmax of 1088 ng/mL and an AUC 0-last of 4581 ng·h/mL.
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• In Vitro:
  IK-930 (0-1 μM) is a potent and selective TEAD inhibitor.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

compound I-32, IK 930, IK930, IK-930, YAP–TEAD

Compound Identifiers

PubChem CID

155342988