IK-595

SKU: orb3210086

Description

IK-595 is a highly potent MEK1/MEK2 inhibitor with a high affinity of 7.39 nM. It blocks EGF-induced ERK1/2 phosphorylation in AsPC-1 cells, with an IC50 value of 0.1 nM. This compound is orally active and capable of crossing the blood-brain barrier, and it can be applied in studies related to cancers with abnormal Ras/MAPK pathways.

Key Properties

• CAS Number: 3018909-73-1
• MW: 675.90
• Formula: C₂₄H₂₄ClFIN₅O₅S
• SMILES: O=C(NC1CC1)C=2C(OC3=CC=CC(NS(=O)(=O)NC)=C3Cl)=C(C(=O)N(C2NC4=CC=C(I)C=C4F)C)C
• Target: MEK,ERK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

MEK,ERK