IITZ-02

SKU: orb3173300

Description

IITZ-02 is a lysosomotropic autophagy inhibitor. It enhances autophagosome accumulation but inhibits autophagosome degradation by impairing lysosomal function, ultimately leading to autophagy suppression. IITZ-02 disrupts mitochondrial membrane potential and induces apoptosis through a mitochondria-mediated pathway. It shows potent anti-tumor activity in MDA-MB-231 xenograft mouse models and is applicable in cancer research.

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 1807988-46-0
• MW: 494.56
• Formula: C₂₇H₂₆N₈O₂
• SMILES: N=1C(=NC(=NC1NC=2C=CC(=CC2)C3=NC=4C=CC=CC4N3)N5CCOCC5)NC6=CC=C(OC)C=C6
• Target: Autophagy,Mitochondrial Metabolism,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Autophagy,Mitochondrial Metabolism,Apoptosis