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IITZ-01

SKU: orb1300454

Description

IITZ-01

Research Area

Cell Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number1807988-47-1
MW482.51
Purity99.00% (May vary between batches)
FormulaC26H23FN8O
SMILESFc1ccc(Nc2nc(Nc3ccc(cc3)-c3nc4ccccc4[nH]3)nc(n2)N2CCOCC2)cc1
TargetAutophagy,PI3K,Apoptosis
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.29 mM);DMSO:150 mg/mL (310.87 mM)

Bioactivity

Target IC50
PI3Kγ:2.62 μM
In Vitro
IITZ-01 enhances autophagosomes formation as indicated by increased expression of LC3-II levels time- and dose-dependently in triple-negative breast cancer (TNBC) cell lines (MDA-MB-231 and MDA-MB-453). IITZ-01 also demonstrates potent autophagy inhibitory activity in other breast, lung, and colon cancer cells.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Apoptosis, Autophagy, inhibit, IITZ 01, IITZ01, IITZ-01, Inhibitor, Phosphoinositide 3-kinase, PI3Kγ, PI3K

Similar Products

  • IITZ-01 [orb1225887]

    >98% (HPLC)

    1807988-47-1

    482.523

    C26H23FN8O

    5 mg, 10 mg, 25 mg, 50 mg, 2 mg, 100 mg, 200 mg, 500 mg, 1 g
Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

IITZ-01 (orb1300454)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 ml x 10 mM (in DMSO)
$ 80.00
5 mg
$ 80.00
10 mg
$ 100.00
25 mg
$ 160.00
50 mg
$ 250.00
100 mg
$ 370.00
200 mg
$ 510.00
DispatchUsually dispatched within 3-5 working days
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