IHVR-17028

SKU: orb1691711

Description

IHVR-17028 is a broad-spectrum α-glucosidase I inhibitor (IC50=0.24 µM) with antiviral activity against viruses such as BVDV, TCRV, and DENV in vitro. This small molecule is a useful research tool for studying host-targeted antiviral strategies and viral pathogenesis in experimental models.

Research Area

Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 1428247-78-2
• MW: 428.61
• Purity: 99.33% (May vary between batches)
• Formula: C₂₃H₄₄N₂O₅
• SMILES: C(CCCCCN(C(C(C)(C)C)=O)C1CCCCC1)N2[C@H](CO)[C@@H](O)[C@H](O)[C@@H](O)C2
• Target: Influenza Virus,glycosidase,Glucosidase
• Solubility: DMSO:30 mg/mL (69.99 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (11.67 mM)

Bioactivity

• Target IC50:
  DENV:0.3 μM|TCRV:0.26 μM|ERα-glucosidase I:0.24 μM|BVDV:0.4 μM
• In Vivo:
  In rats, during pharmacokinetic analysis, IHVR17028 (75 mg/kg, oral gavage) demonstrates a C max value of 0.18 μg/ml. The T max value is 1.56 hours, and after PO administration, the F% value is 12%. The T 1/2 value is 0.88 hours after iv administration. In a mouse model of lethal MARV infection, IHVR-17028 treatment (25-50 mg/kg, oral gavage) one day before virus challenging exhibits significant protection.
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• In Vitro:
  IHVR-17028 demonstrates potent antiviral activity against bovine viral diarrhea virus (BVDV) (NADL strain), tacaribe virus (TCRV) (11573 strain), and DENV (serotype 2, New Guinea C) with EC50 values of 0.4 μM, 0.26 μM, and 0.3 μM, respectively, in virus yield reduction assays. Furthermore, IHVR-17028 exhibits high cell viability with IC50 values exceeding 500 μM in MDBK, Huh7.5, and BHK cells, as determined by MTT assays.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

α-glucosidase, InfluenzaVirus, Influenza virus, Influenza Virus, IHVR 17028, IHVR17028, IHVR-17028

Compound Identifiers

PubChem CID

71580338