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IHR-1

SKU: orb1217892

Description

IHR-1 is a Potent Smo antagonist (IC50 = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in primary cilium in vitro.

Images & Validation

Key Properties

CAS Number548779-60-8
MW454.12
Purity>98% (HPLC)
FormulaC20H12Cl4N2O2
SMILESC1=CC(=CC=C1NC(=O)C2=C(C=CC(=C2)Cl)Cl)NC(=O)C3=C(C=CC(=C3)Cl)Cl
TargetSmoothened (Smo)
SolubilityDMSO:9.08 mg/mL

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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    C20H12Cl4N2O2

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Protocol Information

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2 mg
$ 130.00
5 mg
$ 170.00
10 mg
$ 240.00
25 mg
$ 410.00
50 mg
$ 570.00
100 mg
$ 840.00
500 mg
$ 1,820.00