IHMT-MST1-58

SKU: orb1687532

Description

IHMT-MST1-58 is a potent, selective, and orally active inhibitor of the STE20-like kinase 1 (MST1) with an IC50 of 23 nM. This small molecule is a valuable research tool for investigating the role of MST1 in diabetes pathophysiology, supporting both in vitro enzymatic studies and in vivo metabolic disease models.

Research Area

Cell Biology, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2414484-25-4
• MW: 438.5
• Purity: 99.92% (May vary between batches)
• Formula: C₂₁H₂₂N₆O₃S
• SMILES: CN1C=2C(N(C)C(=O)C1C3=C(C)C=CC=C3)=CN=C(NC4=CC=C(S(N)(=O)=O)C=C4)N2
• Target: Hippo pathway
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.53 mM);DMSO:90 mg/mL (205.25 mM)

Bioactivity

• Target IC50:
  MST2:652 nM|MST1:23 nM|MST1:240 nM(kd)
• In Vivo:
  IHMT-MST1-58 (p.o, 50 mg/kg/day, QD) combined with metformin resulted in the reduction of fasting blood glucose, demonstrating the protective effect on β cells and decrease in hemoglobin A1c levels in the STZ-induced T1D/T2D mouse models.
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• In Vitro:
  IHMT-MST1-58 (0.1-10 μM; 1-2 h) inhibits the phosphorylation of MST1 in vitro. IHMT-MST1-58 (0.03, 0.1 and 0.3 μM; 48 h) exhibits a significant protective effect of β cells from the damage caused by inflammatory cytokines.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Hippo pathway, Hippopathway, MST1

Compound Identifiers

PubChem CID

162477909