IHCH-3185

SKU: orb3210868

Description

IHCH-3185 is an orally active Class I HDAC inhibitor (HDAC1 IC50=102.9 nM) and A2AR antagonist (A2AR Ki=7.6 nM). It reverses immune gene silencing by inducing histone acetylation and blocks adenosine signaling, thus lifting T cell suppression. IHCH-3185 exhibits antiproliferative activity and induces cell cycle arrest while significantly improving the tumor microenvironment. It reduces the proportion of regulatory T cells, increases the CD8+/Treg ratio, and upregulates key factors like H2-K1, Cxcl9, and Cxcl10 expression. Demonstrating substantial antitumor potential in CT26 and MC38 mouse tumor models, IHCH-3185 is suitable for cancer research.

Key Properties

• Target: Adenosine Receptor,HDAC

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

Adenosine Receptor,HDAC