Iguratimod

SKU: orb1302153

Description

Iguratimod (T-614) is a selective COX-2 inhibitor (IC50 = 20 µM) and macrophage migration inhibitory factor (MIF) antagonist (IC50 = 6.81 µM). This small molecule is a research tool for studying rheumatoid arthritis mechanisms and has demonstrated anti-inflammatory and immunomodulatory effects in both cellular and animal models of disease.

Research Area

Immunology & Inflammation, Neuroscience

Key Properties

• CAS Number: 123663-49-0
• MW: 374.37
• Purity: 99.96% (May vary between batches)
• Formula: C₁₇H₁₄N₂O₆S
• SMILES: O=C1C=2C(=CC(NS(C)(=O)=O)=C(OC3=CC=CC=C3)C2)OC=C1NC=O
• Target: COX,MIF
• Solubility: DMSO:10 mg/mL (26.71 mM)

Bioactivity

• Target IC50:
  COX-2:20μM|MIF:6.81μM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Iguratimod, MIF, inhibit, Inhibitor, Cyclooxygenase, COX-2, COX, T614, T-614, T 614

Compound Identifiers

PubChem CID

124246