iGOT1-01

SKU: orb1298651

Description

iGOT1-01

Key Properties

• CAS Number: 882256-55-5
• MW: 320.39
• Purity: 99.83% (May vary between batches)
• Formula: C₁₉H₂₀N₄O
• SMILES: O=C(Nc1ccccc1)N1CCN(CC1)c1cccc2[nH]ccc12
• Target: Others
• Solubility: DMSO:98 mg/mL (305.88 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (10.3 mM)

Bioactivity

• Target IC50:
  GOT1/MDH1:84.6 μM|GOT1/GLOX/HRP:11.3 μM
• In Vivo:
  In female CD1 mice, iGOT1-01 (20 mg/kg; oral) has reasonable bioavailability and exposure properties (t1/2=0.7 hours, Cmax=4133 ng/mL, AUC(0-24 hours)=11734 hour ng/mL).
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• In Vitro:
  iGOT1-01 (3.125-200 μM; for 3 h) reveals little to no toxicity using two readouts of cell viability in PaTu8902 pancreatic and DLD1 colon cancer cells. No inhibitory activity is observed for iGOT1-01 against MDH1 alone at 100 μM.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

aspartate, anti-cancer, aminotransferase, Inhibitor, iGOT1 01, iGOT101, iGOT1-01, MDH, HRP, GLOX, glutamate, GOT1, oxaloacetate, inhibit, transaminase

Compound Identifiers

PubChem CID

2818038