IDO5L

SKU: orb1305221

Description

IDO5L (INCB024360 analogue) is a potent small molecule inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1) with an IC50 of 10 nM. It is a valuable research tool for investigating IDO1's role in immunology and oncology, applicable in both in vitro enzymatic assays and in vivo models of cancer and autoimmune disorders.

Research Area

Metabolism Research

Key Properties

• CAS Number: 914471-09-3
• MW: 271.64
• Purity: >99.99% (May vary between batches)
• Formula: C₉H₇ClFN₅O₂
• SMILES: Nc1nonc1\C(Nc1ccc(F)c(Cl)c1)=N/O
• Target: IDO,Indoleamine 2,3-Dioxygenase (IDO)
• Solubility: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:5 mg/mL (18.41 mM);Ethanol:27.2 mg/mL (100.13 mM);DMSO:50 mg/mL (184.07 mM)

Bioactivity

• Target IC50:
  IDO1:10 nM
• In Vivo:
  INCB024360 significantly inhibits IDO1 in HeLa cells (IC50 = 19 nM) and promotes differentiation in CD4+ T cells, CD8+ T cells, and NK cells.
• In Vitro:
  In an immunologically active mouse model, INCB024360 effectively inhibited tumor growth. Similarly, in mice bearing GM-CSF-secreting B16 tumors, INCB024360 (75 mg/kg b.i.d) demonstrated dose-dependent tumor growth suppression.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

IDO, IDO5L, IDO-5L, IDO1, Inhibitor, inhibit, Indoleamine2,3Dioxygenase(IDO), Indoleamine 2,3-Dioxygenase (IDO), Indoleamine2,3Dioxygenase, Indoleamine 2,3-Dioxygenase, Indoleamine 2,3Dioxygenase (IDO), INCB14943, INCB-14943, INCB 14943, INCB024360 analogue

Compound Identifiers

PubChem CID

135424953