IDO-IN-1

SKU: orb1300004

Description

IDO-IN-1 is a potent and selective inhibitor of indoleamine 2,3-dioxygenase (IDO), demonstrating high potency in both enzymatic (IC50 = 59 nM) and cellular (IC50 = 12 nM in HeLa cells) assays. This small molecule is a valuable research tool for investigating IDO-mediated tryptophan metabolism and immune modulation in cancer and inflammatory disease research, both in vitro and in vivo.

Research Area

Metabolism Research

Key Properties

• CAS Number: 914638-30-5
• MW: 316.09
• Purity: 99.91% (May vary between batches)
• Formula: C₉H₇BrFN₅O₂
• SMILES: Nc1nonc1\C(Nc1ccc(F)c(Br)c1)=N\O
• Target: Indoleamine 2,3-Dioxygenase (IDO),IDO
• Solubility: DMSO:682 mg/mL (2157.61 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (15.82 mM)

Bioactivity

• Target IC50:
  IDO (human):59 nM |IDO (HeLa cells):12 nM
• In Vitro:
  IDO-IN-1 is inactive against tryptophan 2,3-dioxygenase (TOD; IC50 > 10 μM).

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

IDOIN1, IDO-IN-1, IDO, IDO IN 1, Indoleamine 2,3-Dioxygenase (IDO), Indoleamine 2,3Dioxygenase (IDO), Indoleamine2,3Dioxygenase, Indoleamine 2,3-Dioxygenase, Indoleamine2,3Dioxygenase(IDO), inhibit, Inhibitor

Compound Identifiers

PubChem CID

135741412