IDH2R140Q-IN-2

SKU: orb1944180

Description

IDH2R140Q-IN-2 is a potent, orally bioavailable inhibitor of the IDH2 R140Q mutant, demonstrating an IC50 of 29 nM against the enzyme. It effectively reduces D2HG levels in TF-1 cells (IC50=10 nM) and in tumor tissue, supporting its application in research models of acute myeloid leukemia (AML).

Research Area

Metabolism Research

Key Properties

• CAS Number: 2749568-16-7
• MW: 484.4
• Purity: 99.92% (May vary between batches)
• Formula: C₂₁H₁₈F₆N₆O
• SMILES: FC(F)(F)C=1C=CC=C(C1)NC=2N=C(N=C(N2)N3CCC(O)C3)NC4=CC=CC(=C4)C(F)(F)F
• Target: Isocitrate Dehydrogenase (IDH),Dehydrogenase

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

IDH2

Compound Identifiers

PubChem CID

159385708