iCRT 14

SKU: orb1221893

Description

iCRT14 is a potent inhibitor of β-catenin-responsive transcription (CRT) that inhibits Wnt signaling in a reporter assay in vitro (IC50 = 40.3 nM). It inhibits the interaction between β-catenin and T cell factor 4 (Tcf4) in quantitative reporter assays of β-catenin/Tcf4 binding (Ki = 53.51 μM).

Key Properties

• CAS Number: 677331-12-3
• MW: 375.44
• Purity: >98% (HPLC)
• Formula: C₂₁H₁₇N₃O₂S
• SMILES: O=C4S\C(=C/c2cc(C)n(c1cccnc1)c2C)C(=O)N4c3ccccc3
• Target: Wnt
• Solubility: DMSO : ≥ 29 mg/mL; 77.24 mM

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

iCRT14 | iCRT-14 | iCRT 14 | Wnt inhibitor

Quick Database Links

Gene Symbol

Wnt