Icopezil

SKU: orb1819168

Description

Icopezil is a small molecule acetylcholinesterase (AChE) inhibitor used in neuroscience research. It serves as a tool compound for investigating cholinergic function in models of Alzheimer's disease and other neurological disorders, applicable in both in vitro enzymatic assays and in vivo behavioral studies.

Research Area

Neuroscience

Key Properties

• CAS Number: 145508-78-7
• MW: 375.46
• Purity: 99.35%
• Formula: C₂₃H₂₅N₃O₂
• SMILES: C(CC1CCN(CC2=CC=CC=C2)CC1)C=3C4=C(C=C5C(=C4)CC(=O)N5)ON3
• Target: Cholinesterase (ChE)
• Solubility: DMSO:50 mg/mL (133.17 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AChE

CAS Number: 145508-78-7

Compound Identifiers

PubChem CID

172972

Ye Bin Shin 1, Jin Hwan Kim 1, Min Kyeong Kwon 1, Jin Hyuk Myung 1, Dong Geon Lee 1, Sung Giu Jin 2, Myung Joo Kang 1, Yong Seok Choi Optimized method development and validation for determining donepezil in rat plasma: A liquid-liquid extraction, LC-MS/MS, and design of experiments approach PLoS One, (2024)

PubMed: 39240870

Min Young Jeong et al. Coupling syringe system comprising drug nanosuspension and photo-crosslinked gelatin methacryloyl hydrogel for subcutaneous delivery with decreased initial exposure Materials & Design, (2025)

PubMed: