ICI 63197

SKU: orb1305794

Description

ICI 63197 is a selective phosphodiesterase 4 (PDE4) inhibitor, chemically defined as 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one. This small molecule is utilized in research to study PDE4-mediated signaling pathways in both cellular and animal models of inflammation and neurological disorders.

Research Area

Metabolism Research

Key Properties

• CAS Number: 27277-00-5
• MW: 207.23
• Purity: 99.70% (May vary between batches)
• Formula: C₉H₁₃N₅O
• SMILES: CCCn1c2nc(N)nn2cc(C)c1=O
• Target: PDE
• Solubility: DMSO:< 20 mg/mL;Ethanol:< 20 mg/mL

Bioactivity

• Target IC50:
  PDE4:10 μM (Ki)|PDE2:>1000 μM (Ki)|PDE3:9 μM (Ki)|PDE1:487 μM (Ki)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PDE4, ICI 63197, ICI63197, ICI-63197, 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one

Compound Identifiers

PubChem CID

62824