ICD inducer-2

SKU: orb3210959

Description

ICD inducer-2 is an inducer of immunogenic cell death that binds to the colchicine binding site on tubulin, thereby inhibiting tubulin polymerization. It demonstrates broad-spectrum antiproliferative activity across various cancer cell lines and inhibits cell migration while causing G2/M phase arrest and inducing apoptosis. Additionally, it promotes CD4+ and CD8+ T cell infiltration into the tumor microenvironment. ICD inducer-2 decreases Bcl-2, an anti-apoptotic protein, and increases pro-apoptotic proteins Bax and Bim-1, as well as cleaved forms of caspase 3, caspase 9, and PARP. It also overcomes paclitaxel resistance in xenograft models, leading to tumor growth inhibition, and is applicable in cancer-related research, such as lung cancer studies.

Key Properties

• CAS Number: 3069681-35-9
• MW: 385.44
• Formula: C₂₂H₁₅N₃O₂S
• SMILES: N#CC1=CN=C2C=C3OCCOC3=CC2=C1NC4=CC=CC(=C4)C=5SC=CC5
• Target: Apoptosis,Caspase,Microtubule Associated,PARP,Bcl-2 Family

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,Caspase,Microtubule Associated,PARP,Bcl-2 Family