ICCB280

SKU: orb1218506

Description

ICCB280 was capable of inducing differentiation and apoptosis of ATRA-resistant patient blasts strongly signify that the activity of this compound can overcome resistance to other current therapies for AML with an unfavorable prognosis.

Key Properties

• CAS Number: 2041072-41-5
• MW: 386.4
• Purity: >98% (HPLC)
• Formula: C₂₃H₁₈N₂O₄
• SMILES: O=C1N(C2=CC=CC=C2OC)C(/C=C/C3=CC=C(O)C(O)=C3)=NC4=C1C=CC=C4
• Target: C/EBPα
• Solubility: DMSO:85mg/mL (219.98mM)

Bioactivity

• In Vitro:
  ICCB280 (0.1-50 μM; 48 h) suppresses the HL-60 cell growth, with an IC50 of 8.6 μM. ICCB280 (10 μM; 2-8 d) increases the C/EBPα expression (mRNA and protein) and modulates its target genes in HL-60 cells. ICCB280 (10 μM; 7 d) induces granulocytic differentiation and subsequent apoptosis in HL-60 cells. Cell Viability Assay Cell line: HL-60 cells. Concentration: 0.1, 0.5, 1, 5, 10, 50 μM Incubation time: 48 hours. Result: Induced cell growth arrest, with an IC50 of 8.6 μM. Western blot analysis. Cell line: HL-60 cells. Concentration: 10 μM. Incubation time: 2, 4, 6, 8 days. Result: Upregulated the C/EBPα protein on day 4.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

C/EBPα