ICCB-19 hydrochloride

SKU: orb1298514

Description

ICCB-19 hydrochloride is a small molecule inhibitor that targets the TRADD-N domain, disrupting its interaction with TRAF2 and TRADD-C. This inhibition modulates RIPK1 and beclin 1 ubiquitination, making it a useful research tool for studying TNF signaling, apoptosis, and autophagy in cellular models.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1803605-68-6
• MW: 291.84
• Purity: 99.30%
• Formula: C₁₂H₂₂ClN₃OS
• SMILES: Cl.O=C(CSC1=NCCN1)NC1CCCCCC1
• Target: RIP kinase,Apoptosis,Autophagy
• Solubility: DMSO:25 mg/mL (85.66 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.85 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RIPkinase, RIPK, RIP kinase, RIPK1, ubiquitination, TRADD, RDA, Receptor-interacting protein kinases, k63, inhibit, Inhibitor, ICCB 19, ICCB 19 hydrochloride, ICCB 19 Hydrochloride, ICCB19, ICCB-19, ICCB-19 HCl, ICCB-19 HCl(750621-52-4 free base), ICCB19 Hydrochloride, ICCB19 hydrochloride, ICCB-19 Hydrochloride, beclin1, Apoptosis, Autophagy, 750621-52-4, 750621-52-4 free base, cIAP2, cIAP1

Compound Identifiers

PubChem CID

91654402