IC 86621

SKU: orb1297892

Description

IC 86621 is a potent, selective, and reversible ATP-competitive inhibitor of DNA-PK, exhibiting an IC50 of 120 nM. It disrupts DNA double-strand break repair with an EC50 of 68 µM in cellular assays, enhancing the antitumor effects of DNA-damaging agents in cancer research models, both in vitro and in vivo.

Research Area

Cell Biology, Molecular Biology, Signal Transduction

Key Properties

• CAS Number: 404009-40-1
• MW: 221.2524
• Purity: 99.68% (May vary between batches)
• Formula: C₁₂H₁₅NO₃
• SMILES: CC(=O)C1=CC=C(C=C1O)N1CCOCC1
• Target: DNA-PK,Apoptosis
• Solubility: DMSO:50 mg/mL (225.99 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (9.04 mM)

Bioactivity

• In Vitro:
  In CD4+CD45RO- T cells, IC 86621 (0 nM, 50 nM, 100 nM) protects rheumatoid arthritis T cells from apoptosis.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DNA-dependent protein kinase, DNAPK, DNA-PK, DSB, Buchwald-Hartwig amination, ATP, Apoptosis, antitumor, Fries rearrangement, Inhibitor, IC 86621, IC86621, IC-86621, inhibit

Compound Identifiers

PubChem CID

9859309