Ibutamoren Mesylate

SKU: orb1300061

Description

Ibutamoren Mesylate (MK-0677) is a selective, orally active agonist of the growth hormone secretagogue receptor (GHSR). It is widely used in research to study growth hormone secretion, aging, and muscle metabolism in both in vitro assays and in vivo animal models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 159752-10-0
• MW: 624.77
• Purity: ≥98% (May vary between batches)
• Formula: C₂₈H₄₀N₄O₈S₂
• SMILES: S(C)(=O)(=O)O.S(C)(=O)(=O)N1CC2(C=3C1=CC=CC3)CCN(C([C@@H](COCC4=CC=CC=C4)NC(C(C)(C)N)=O)=O)CC2
• Target: GHSR
• Solubility: DMSO:252.5 mg/mL (404.15 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.2 mM)

Bioactivity

• In Vivo:
  Following oral administration Ibutamoren Mesylate(MK0677) amplifies episodic GH release. Mechanistically, it synergizes with growth hormone releasing hormone (GHRH) through a receptor and signal transduction pathway distinct from that of GHRH and is a functional antagonist of somatostatin (SRIF). MK0677 also acts on the arcuate nucleus and appears to stimulate GHRH release. By using 35S-MK0677, a new G-protein coupled receptor for MK0677 was characterized in the plasma membrane fraction of pituitary and hypothalamic tissue. The receptor is present in very low abundance and couples to phospholipase C. Other ligands selective for this receptor also cause synchronization of well-defined pathways leading to GH release. Repeated oral treatment of dogs once daily with MK0677 initiates amplified pulsatile GH release accompanied by increases in IGF-1 that are sustained. The unique biological properties of MK0677 and other synthetic ligands that bind to the same receptor force us to predict that these ligands mimic a naturally occurring hormone that regulates pulsatile GH release.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GHS-R, GHSR, Growth hormone secretagogue receptor, Inhibitor, Ibutamoren, Ibutamoren Mesylate, MK0677, MK-0677, MK 677, MK 0677, MK677, MK-677, inhibit

Compound Identifiers

PubChem CID

6450830