Ibrutinib deacryloylpiperidine

SKU: orb1298758

Description

IBT4A is a potent and highly selective irreversible inhibitor of Bruton's tyrosine kinase (BTK), exhibiting an IC50 of 0.5 nM. It is a valuable research tool for studying BTK-dependent signaling pathways in both cellular and animal models of B-cell malignancies and autoimmune disorders.

Research Area

Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 330786-24-8
• MW: 303.32
• Purity: 99.80% (May vary between batches)
• Formula: C₁₇H₁₃N₅O
• SMILES: Nc1ncnc2[nH]nc(-c3ccc(Oc4ccccc4)cc3)c12
• Target: BTK
• Solubility: DMSO:10 mg/mL (32.97 mM)

Bioactivity

• Target IC50:
  BTK:0.5 nM.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyriMidin-4-ylaMine, Btk, Bruton tyrosine kinase, Inhibitor, Ibrutinib deacryloylpiperidine, IBT4A, inhibit

Compound Identifiers

PubChem CID

22346757