Ibotenic acid

SKU: orb1679003

Description

Ibotenic acid acts as a dual agonist, activating both NMDA-type and metabotropic glutamate receptors (mGluRs). This property makes it a valuable research tool for studying excitatory neurotransmission, neurotoxicity, and glutamate receptor function in various in vitro and in vivo experimental models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2552-55-8
• MW: 158.11
• Purity: 99.70% (May vary between batches)
• Formula: C₅H₆N₂O₄
• SMILES: NC(C(O)=O)c1cc(=O)[nH]o1
• Target: NMDAR,iGluR
• Solubility: H2O:5 mg/mL (31.62 mM);DMSO:140 mg/mL (885.46 mM)

Bioactivity

• In Vitro:
  Ibotenic acid is toxic to cortical neurons exposes for 5 min with an EC50=77.3 μM as measured by the release of lactate dehydrogenase to the culture media.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NMDA receptor, Ibotenate, Ibotenic acid, (RS)-Ibotenic acid, (+/-)-Ibotenic acid, DL-Ibotenic acid

Compound Identifiers

PubChem CID

1233