Ibetazol

SKU: orb2814652

Description

Ibetazol is a cell-permeable small molecule inhibitor of nuclear import protein KPNB1 (importin β1). It covalently binds to Cys585, blocking importin β1-mediated nuclear transport with an EC50 of 6.1 µM. This inhibitor is used in vitro to study nucleocytoplasmic transport, viral infection mechanisms, and cancer cell signaling pathways.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• MW: 300.3
• Formula: C₁₃H₁₁F₃N₂OS
• Target: Ras

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Ras