Iberdomide

SKU: orb1299503

Description

Iberdomide

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1323403-33-3
• MW: 449.5
• Purity: 97.01%
• Formula: C₂₅H₂₇N₃O₅
• SMILES: O(CC1=CC=C(CN2CCOCC2)C=C1)C3=C4C(C(=O)N(C4)[C@@H]5C(=O)NC(=O)CC5)=CC=C3
• Target: E3 Ligase Ligand-Linker Conjugates,Ligands for E3 Ligase,Apoptosis,Molecular Glues
• Solubility: DMSO:50 mg/mL (111.23 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.45 mM)

Bioactivity

• Target IC50:
  Cereblon:60 nM
• In Vitro:
  Iberdomide has a greater potency for degrading the CRL4 complex substrates Ikaros and Aiolos (EC50s = 1 and 0.5 nM) but has no degradative activity for GSPT1 or CK1α.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cereblon, CELMoD, CC220, CC-220, CC 220, CRBN, E3 ligase-recruiting Moiety, Apoptosis, orally, MM1.R, MM1.S, Ligand for E3 Ligase, ligase, Ligands for E3 Ligase, LigandforE3Ligase, KMS11, KMS128M, KMS12PE, inhibit, myeloma, multiple, Inhibitor, G0/G1, EJM, Iberdomide, H929, RPM-8226, sub-G1, Thalidomide, U266

Compound Identifiers

PubChem CID

67335295