IAM1363

SKU: orb3177575

Description

IAM1363 is a highly potent and irreversible small-molecule HER2 tyrosine kinase inhibitor with a unique Type II DFG-out binding mode. It targets and inhibits both wild-type HER2 and various oncogenic HER2 mutants, and possesses excellent blood-brain barrier permeability, demonstrating therapeutic potential for HER2-driven cancers and their brain metastases. IAM1363 demonstrates good antitumor activity and tolerability in various HER2-mutated tumor models.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 3031413-24-5
• MW: 551.64
• Formula: C₃₀H₃₃N₉O₂
• SMILES: N(C=1C2=C(C=CN2N=CN1)C3CCN(C(/C=C/CN(C)C)=O)CC3)C4=CC(C)=C(OC5=CC=6N(C=C5)N=CN6)C=C4
• Target: EGFR,HER

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

EGFR,HER