IACS-56676

SKU: orb3210204

Description

IACS-56676 is a selective inhibitor of NRASG12D with a target Kd of 0.031 μM. It stabilizes the p-loop, maintaining crucial interactions with Asp12, Gly60, and Asp69, and achieves selectivity for wild-type KRAS through substitution targeting Leu95. IACS-56676 is applicable for research in melanoma, hematologic malignancies, and thyroid cancer.

Key Properties

• CAS Number: 3105153-34-9
• MW: 562.00
• Formula: C₂₈H₂₈ClF₄N₅O
• SMILES: C(NC(C)=O)C1=C(C=2C(N1C3CC3)=C(F)C(=NC2C4CC4)C5=C(C(F)(F)F)C(Cl)=CC(N)=C5)[C@@H]6[C@@]7([C@]6(CNC7)[H])[H]
• Target: Ras

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Ras