IACS-4619

SKU: orb3210332

Description

IACS-4619 (compound 4) is a highly selective 2-aminopyridine-based MTH1 (MutT homolog 1) inhibitor with an IC50 of 0.2 nM. By inhibiting MTH1 from hydrolyzing oxidized purine nucleotides like 8-oxo-dGTP, it prevents MTH1 from stopping the incorporation of these nucleotides into DNA. In MTH1-overexpressing U2OS cells, IACS-4619 significantly inhibits endogenous MTH1 activity, yet it shows no substantial antiproliferative or cytotoxic effects on various human cancer or normal cell lines. IACS-4619 can be utilized for MTH1-targeted research within the field of oncology.

Key Properties

• CAS Number: 1884209-98-6
• MW: 195.26
• Formula: C₁₀H₁₇N₃O
• SMILES: N=1C=C(C(=NC1N)OCC(C)(C)C)C
• Target: DNA/RNA Synthesis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

DNA/RNA Synthesis