IACS-15414

SKU: orb1818759

Description

IACS-15414 (IACS 15414) is a potent, selective, orally bioavailable SHP2 inhibitor with IC50 of 122 nM; IACS-15414 potently suppressed the mitogen-activated protein kinase (MAPK) pathway signaling and tumor growth in RTK-activated and KRASmut xenograft models in vivo. IACS-15414 potently suppressed the mitogen-activated protein kinase (MAPK) pathway signaling and tumor growth. IACS-15414 had excellent PK properties across species but a narrow hERG window.

Key Properties

• CAS Number: 2411321-29-2
• MW: 423.336162567139
• Purity: >98%
• Formula: C₂₀H₂₄CL₂N₄O₂
• SMILES: C1(C)=NC(N2CCC3(CO[C@@H](C)[C@H]3N)CC2)=CC(=O)N1C1=CC=CC(Cl)=C1Cl

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

146364381