IA-Alkyne

SKU: orb1308213

Description

IA-Alkyne is a TRPC channel agonist used to create isotopically tagged probes for quantitative cysteine-reactivity profiling. Its applications extend to studying respiratory infections in both in vitro and in vivo experimental models, facilitating research in chemical proteomics and host-pathogen interactions.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 930800-38-7
• MW: 265.09
• Purity: 99.76% (May vary between batches)
• Formula: C₈H₁₂INO
• SMILES: C(NC(CI)=O)CCCC#C
• Target: TRP/TRPV Channel
• Solubility: DMSO:55 mg/mL (207.48 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.54 mM)

Bioactivity

• In Vitro:
  IA-alkyne (2.5-10 μM; 1 hour) reacts with cysteines. In-gel fluorescence imaging indicates strong fluorescent intensity of IA-alkyne. Labeled proteome samples are conjugated with a fluorescent rhodamine-azide tag via CuAAC and analyzed by SDS-PAGE. Soluble fractions of HeLa cell lysates (2.0 mg/ml) are treated with IA-alkyne .

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TRP Channel, TRPC, TRPChannel, TRPV Channel, TRPVChannel, Transient receptor potential channels, emphysema, Fluorescence, IA Alkyne, IAAlkyne, IA-Alkyne, gel, Inhibitor, imaging, Iodoacetamide-alkyne, inhibit, N-Hex-5-ynyl-2-iodo-acetamide, obstructive, asthma, bronchiectasis, cysteine, cystic fibrosis, chronic, chronic bronchitis

Compound Identifiers

PubChem CID

44448710