I3MT-3

SKU: orb1298582

Description

I3MT-3 (HMPSNE) is a potent, selective, and cell-permeable inhibitor targeting the persulfated cysteine residues in the active site of 3-mercaptopyruvate sulfurtransferase (3MST). It is a valuable chemical tool for investigating hydrogen sulfide signaling pathways in both cellular and animal models of related diseases.

Research Area

Stem Cell & Developmental Biology

Key Properties

• CAS Number: 459420-09-8
• MW: 310.37
• Purity: 99.86% (May vary between batches)
• Formula: C₁₇H₁₄N₂O₂S
• SMILES: Cc1cc(=O)[nH]c(SCC(=O)c2cccc3ccccc23)n1
• Target: Hippo pathway
• Solubility: 10% DMSO+90% Corn Oil:3.3 mg/mL (10.63 mM);DMSO:120 mg/mL (386.64 mM)

Bioactivity

• Target IC50:
  Hippo pathway:2.7 μM
• In Vitro:
  I3MT-3 shows a dose-dependent inhibition of 3-MST activity from CT26 homogenates, which contain the murine form of the enzyme. The IC50 of HMPSNE for murine 3-MST is calculated as 2.3 μM with a cozncentration-dependent decrease of AzMC fluorescence.I3MT-3 (0-300 μM; 48 hours) inhibits CT26 cells proliferate with increasing concentrations of I3MT-3. Confluence of cells treated with HMPSNE is recorded each hour for 48 h by the IncuCyte method.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, MST3, Hippopathway, Hippo (MST), Hippo pathway, HMPSNE, I3MT 3, I3MT3, I-3MT-3, I3MT-3, Inhibitor, HEK293, EA.hy926 cells, 3MST, COS-7, cell-membrane

Compound Identifiers

PubChem CID

135412420