I3IN-002

SKU: orb3135522

Description

I3IN-002 is a small molecule inhibitor targeting the RNA-binding protein IGF2BP3, with an IC50 value of approximately 2 μM in SEM cells. It disrupts the interaction with m6A-modified mRNA, destabilizing target genes (such as CDK6, MYC, and BCL2), thereby inhibiting the growth of leukemia cells, inducing cell cycle arrest, and promoting apoptosis. I3IN-002 shows potential for research in B-cell acute lymphoblastic leukemia.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 552829-57-9
• MW: 431.43
• Formula: C₂₀H₁₆F₃N₅OS
• SMILES: O=C(NC=1C=CC=CC1C(F)(F)F)CSC=2N=NC3=C(N2)NC4=CC=C(C=C34)CC
• Target: IGF-1R,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

IGF-1R,Apoptosis