I-OMe-Tyrphostin AG 538

SKU: orb1709458

Description

I-OMe-Tyrphostin AG 538

Research Area

Signal Transduction

Key Properties

• CAS Number: 1094048-77-7
• MW: 437.19
• Purity: 96.66% (May vary between batches)
• Formula: C₁₇H₁₂INO₅
• SMILES: COc1cc(\C=C(/C#N)C(=O)c2ccc(O)c(O)c2)cc(I)c1O
• Target: PI3K,IGF-1R
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.57 mM);DMSO:50 mg/mL (114.37 mM)

Bioactivity

• Target IC50:
  PI5P4Kα:1 µM
• In Vitro:
  I-OMe Tyrhost AG 538 (0-3 µM; 1 hour) can prevent the phosphorylation of Akt, IGF-1R, and Erk. I-OMe Tyrphostin AG 538 (0.1-1000 µM; 24 hours) has cytotoxicity on PANC-1 cells in nutrient deficient culture medium.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

I-OMe-AG 538, I-OMe-AG538, I-OMe-AG-538, I-OMe-Tyrphostin AG-538, I-OMe-Tyrphostin AG538, I-OMe-Tyrphostin AG 538, IGF1R, IGF-1R, PI5P4Kα

Compound Identifiers

PubChem CID

5353685